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The goal of investigational neurotrophic agents is to promote motor neuron growth, repair, and survival regardless of which cellular mechanisms are damaged

The elevated testosterone then aggravates insulin resistance even more , perpetuating the cycle

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2.3.1 The relationship between ferroptosis and autophagy Appropriate autophagy has evolved into a pro-survival response for cells, but excessive autophagy, especially selective autophagy, and impaired lysosomal activity may promote cellular ferroptosis (92)